Epidemics after Natural Disasters
John T. Watson,* Michelle Gayer,* and Maire A. Connolly*
*World Health Organization, Geneva, Switzerland
Suggested citation for this article
Abstract
The relationship between natural disasters and communicable diseases is frequently misconstrued. The risk for outbreaks is often presumed to be very high in the chaos that follows natural disasters, a fear likely derived from a perceived association between dead bodies and epidemics. However, the risk factors for outbreaks after disasters are associated primarily with population displacement. The availability of safe water and sanitation facilities, the degree of crowding, the underlying health status of the population, and the availability of healthcare services all interact within the context of the local disease ecology to influence the risk for communicable diseases and death in the affected population. We outline the risk factors for outbreaks after a disaster, review the communicable diseases likely to be important, and establish priorities to address communicable diseases in disaster settings.
Natural disasters are catastrophic events with atmospheric, geologic, and hydrologic origins. Disasters include earthquakes, volcanic eruptions, landslides, tsunamis, floods, and drought. Natural disasters can have rapid or slow onset, with serious health, social, and economic consequences. During the past 2 decades, natural disasters have killed millions of people, adversely affected the lives of at least 1 billion more people, and resulted in substantial economic damages (1). Developing countries are disproportionately affected because they may lack resources, infrastructure, and disaster-preparedness systems.
Deaths associated with natural disasters, particularly rapid-onset disasters, are overwhelmingly due to blunt trauma, crush-related injuries, or drowning. Deaths from communicable diseases after natural disasters are less common.
Dead Bodies and Disease
The sudden presence of large numbers of dead bodies in the disaster-affected area may heighten concerns of disease outbreaks (2), despite the absence of evidence that dead bodies pose a risk for epidemics after natural disasters (3). When death is directly due to the natural disaster, human remains do not pose a risk for outbreaks (4). Dead bodies only pose health risks in a few situations that require specific precautions, such as deaths from cholera (5) or hemorrhagic fevers (6). Recommendations for management of dead bodies are summarized in the Table.
Despite these facts, the risk for outbreaks after disasters is frequently exaggerated by both health officials and the media. Imminent threats of epidemics remain a recurring theme of media reports from areas recently affected by disasters, despite attempts to dispel these myths (2,3,7).
Displacement: Primary Concern
The risk for communicable disease transmission after disasters is associated primarily with the size and characteristics of the population displaced, specifically the proximity of safe water and functioning latrines, the nutritional status of the displaced population, the level of immunity to vaccine-preventable diseases such as measles, and the access to healthcare services (8). Outbreaks are less frequently reported in disaster-affected populations than in conflict-affected populations, where two thirds of deaths may be from communicable diseases (9). Malnutrition increases the risk for death from communicable diseases and is more common in conflict-affected populations, particularly if their displacement is related to long-term conflict (10).
Although outbreaks after flooding (11) have been better documented than those after earthquakes, volcanic eruptions, or tsunamis (12), natural disasters (regardless of type) that do not result in population displacement are rarely associated with outbreaks (8). Historically, the large-scale displacement of populations as a result of natural disasters is not common (8), which likely contributes to the low risk for outbreaks overall and to the variability in risk among disasters of different types.
Risk Factors for Communicable Disease Transmission
Responding effectively to the needs of the disaster-affected population requires an accurate communicable disease risk assessment. The efficient use of humanitarian funds depends on implementing priority interventions on the basis of this risk assessment.
A systematic and comprehensive evaluation should identify 1) endemic and epidemic diseases that are common in the affected area; 2) living conditions of the affected population, including number, size, location, and density of settlements; 3) availability of safe water and adequate sanitation facilities; 4) underlying nutritional status and immunization coverage among the population; and 5) degree of access to healthcare and to effective case management.
Communicable Diseases Associated with Natural Disasters
The following types of communicable diseases have been associated with populations displaced by natural disasters. These diseases should be considered when postdisaster risk assessments are performed.
Water-related Communicable Diseases
Access to safe water can be jeopardized by a natural disaster. Diarrheal disease outbreaks can occur after drinking water has been contaminated and have been reported after flooding and related displacement. An outbreak of diarrheal disease after flooding in Bangladesh in 2004 involved >17,000 cases; Vibrio cholerae (O1 Ogawa and O1 Inaba) and enterotoxigenic Escherichia coli were isolated (13). A large (>16,000 cases) cholera epidemic (O1 Ogawa) in West Bengal in 1998 was attributed to preceding floods (14), and floods in Mozambique in January–March 2000 led to an increase in the incidence of diarrhea (15).
In a large study undertaken in Indonesia in 1992–1993, flooding was identified as a significant risk factor for diarrheal illnesses caused by Salmonella enterica serotype Paratyphi A (paratyphoid fever) (16). In a separate evaluation of risk factors for infection with Cryptosporidium parvum in Indonesia in 2001–2003, case-patients were >4× more likely than controls to have been exposed to flooding (17).
The risk for diarrheal disease outbreaks following natural disasters is higher in developing countries than in industrialized countries (8,11). In Aceh Province, Indonesia, a rapid health assessment in the town of Calang 2 weeks after the December 2004 tsunami found that 100% of the survivors drank from unprotected wells and that 85% of residents reported diarrhea in the previous 2 weeks (18). In Muzaffarabad, Pakistan, an outbreak of acute watery diarrhea occurred in an unplanned, poorly equipped camp of 1,800 persons after the 2005 earthquake. The outbreak involved >750 cases, mostly in adults, and was controlled after adequate water and sanitation facilities were provided (19). In the United States, diarrheal illness was noted after Hurricanes Allison (20) and Katrina (21–23), and norovirus, Salmonella, and toxigenic and nontoxigenic V. cholerae were confirmed among Katrina evacuees.
Hepatitis A and E are also transmitted by the fecal-oral route, in association with lack of access to safe water and sanitation. Hepatitis A is endemic in most developing countries, and most children are exposed and develop immunity at an early age. As a result, the risk for large outbreaks is usually low in these settings. In hepatitis E–endemic areas, outbreaks frequently follow heavy rains and floods; the illness is generally mild and self-limited, but for pregnant women case-fatality rates can reach 25% (24). After the 2005 earthquake in Pakistan, sporadic hepatitis E cases and clusters were common in areas with poor access to safe water. Over 1,200 cases of acute jaundice, many confirmed as hepatitis E, occurred among the displaced (25). Clusters of both hepatitis A and hepatitis E were noted in Aceh after the December 2004 tsunami (26).
Leptospirosis is an epidemic-prone zoonotic bacterial disease that can be transmitted by direct contact with contaminated water. Rodents shed large amounts of leptospires in their urine, and transmission occurs through contact of the skin and mucous membranes with water, damp soil or vegetation (such as sugar cane), or mud contaminated with rodent urine. Flooding facilitates spread of the organism because of the proliferation of rodents and the proximity of rodents to humans on shared high ground. Outbreaks of leptospirosis occurred in Taiwan, Republic of China, associated with Typhoon Nali in 2001 (27); in Mumbai, India, after flooding in 2000 (28); in Argentina after flooding in 1998 (29); and in the Krasnodar region of the Russian Federation in 1997 (30). After a flooding-related outbreak of leptospirosis in Brazil in 1996, spatial analysis indicated that incidence rates of leptospirosis doubled inside the flood-prone areas of Rio de Janeiro (31).
Diseases Associated with Crowding
Crowding is common in populations displaced by natural disasters and can facilitate the transmission of communicable diseases. Measles and the risk for transmission after a natural disaster are dependent on baseline immunization coverage among the affected population, and in particular among children <15 years of age. Crowded living conditions facilitate measles transmission and necessitate even higher immunization coverage levels to prevent outbreaks (32). A measles outbreak in the Philippines in 1991 among persons displaced by the eruption of Mt. Pinatubo involved >18,000 cases (33). After the tsunami in Aceh, a cluster of measles involving 35 cases occurred in Aceh Utara district, and continuing sporadic cases and clusters were common despite mass vaccination campaigns (26). In Pakistan, after the 2005 South Asia earthquake, sporadic cases and clusters of measles (>400 clinical cases in the 6 months after the earthquake) also occurred (25).
Neisseria meningitidis meningitis is transmitted from person to person, particularly in situations of crowding. Cases and deaths from meningitis among those displaced in Aceh and Pakistan have been documented (25,26). Prompt response with antimicrobial prophylaxis, as occurred in Aceh and Pakistan, can interrupt transmission. Large outbreaks have not been recently reported in disaster-affected populations but are well-documented in populations displaced by conflict (34).
Acute respiratory infections (ARI) are a major cause of illness and death among displaced populations, particularly in children <5 years of age. Lack of access to health services and to antimicrobial agents for treatment further increases the risk for death from ARI. Risk factors among displaced persons include crowding, exposure to indoor cooking using open flame, and poor nutrition. The reported incidence of ARI increased 4-fold in Nicaragua in the 30 days after Hurricane Mitch in 1998 (35), and ARI accounted for the highest number of cases and deaths among those displaced by the tsunami in Aceh in 2004 (26) and by the 2005 earthquake in Pakistan (25).
Vectorborne Diseases
Natural disasters, particularly meteorologic events such as cyclones, hurricanes, and flooding, can affect vector-breeding sites and vectorborne disease transmission. While initial flooding may wash away existing mosquito-breeding sites, standing water caused by heavy rainfall or overflow of rivers can create new breeding sites. This situation can result (with typically some weeks\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\' delay) in an increase of the vector population and potential for disease transmission, depending on the local mosquito vector species and its preferred habitat. The crowding of infected and susceptible hosts, a weakened public health infrastructure, and interruptions of ongoing control programs are all risk factors for vectorborne disease transmission (36).
Malaria outbreaks in the wake of flooding are a well-known phenomenon. An earthquake in Costa Rica\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s Atlantic Region in 1991 was associated with changes in habitat that were beneficial for breeding and preceded an extreme rise in malaria cases (37). Additionally, periodic flooding linked to El Niño–Southern Oscillation has been associated with malaria epidemics in the dry coastal region of northern Peru (38).
Dengue transmission is influenced by meteorologic conditions, including rainfall and humidity, and often exhibits strong seasonality. However, transmission is not directly associated with flooding. Such events may coincide with periods of high risk for transmission and may be exacerbated by increased availability of the vector\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s breeding sites (mostly artificial containers) caused by disruption of basic water supply and solid waste disposal services. The risk for outbreaks can be influenced by other complicating factors, such as changes in human behavior (increased exposure to mosquitoes while sleeping outside, movement from dengue-nonendemic to -endemic areas, a pause in disease control activities, overcrowding) or changes in the habitat that promote mosquito breeding (landslide, deforestation, river damming, and rerouting of water).
Other Diseases Associated with Natural Disasters
Tetanus is not transmitted person to person but is caused by a toxin released by the anaerobic tetanus bacillus Clostridium tetani. Contaminated wounds, particularly in populations where vaccination coverage levels are low, are associated with illness and death from tetanus. A cluster of 106 cases of tetanus, including 20 deaths, occurred in Aceh and peaked 2 1/2 weeks after the tsunami (26). Cases were also reported in Pakistan following the 2005 earthquake (25).
An unusual outbreak of coccidiomycosis occurred after the January 1994 Southern California earthquake. The infection is not transmitted person to person and is caused by the fungus Coccidioides immitis, which is found in soil in certain semiarid areas of North and South America. This outbreak was associated with exposure to increased levels of airborne dust subsequent to landslides in the aftermath of the earthquake (39).
Disaster-related Interruption of Services
Power cuts related to disasters may disrupt water treatment and supply plants, thereby increasing the risk for waterborne diseases. Lack of power may also affect proper functioning of health facilities, including preservation of the vaccine cold chain. An increase in diarrheal illness in New York City followed a massive power outage in 2003. The blackout left 9 million people in the area without power for several hours to 2 days. Diarrhea cases were widely dispersed and detected by using nontraditional surveillance techniques. A case-control study performed as part of the outbreak investigation linked diarrheal illness with the consumption of meat and seafood after the onset of the power outage, when refrigeration facilities were widely interrupted (40).
Discussion
Historically, fears of major disease outbreaks in the aftermath of natural disasters have shaped the perceptions of the public and policymakers. These expectations, misinformed by associations of disease with dead bodies, can create fear and panic in the affected population and lead to confusion in the media and elsewhere.
The risk for outbreaks after natural disasters is low, particularly when the disaster does not result in substantial population displacement. Communicable diseases are common in displaced populations that have poor access to basic needs such as safe water and sanitation, adequate shelter, and primary healthcare services. These conditions, many favorable for disease transmission, must be addressed immediately with the rapid reinstatement of basic services. Assuring access to safe water and primary healthcare services is crucial, as are surveillance and early warning to detect epidemic-prone diseases known to occur in the disaster-affected area. A comprehensive communicable disease risk assessment can determine priority diseases for inclusion in the surveillance system and prioritize the need for immunization and vector-control campaigns. Five basic steps that can reduce the risk for communicable disease transmission in populations affected by natural disasters are summarized in an online table (Appendix Table).
Disaster-related deaths are overwhelmingly caused by the initial traumatic impact of the event. Disaster-preparedness plans, appropriately focused on trauma and mass casualty management, should also take into account the health needs of the surviving disaster-affected populations. The health effects associated with the sudden crowding of large numbers of survivors, often with inadequate access to safe water and sanitation facilities, will require planning for both therapeutic and preventive interventions, such as the rapid delivery of safe water and the provision of rehydration materials, antimicrobial agents, and measles vaccination materials.
Surveillance in areas affected by disasters is fundamental to understanding the impact of natural disasters on communicable disease illness and death. Obtaining relevant surveillance information in these contexts, however, is frequently challenging. The destruction of the preexisting public health infrastructure can aggravate (or eliminate) what may have been weak predisaster systems of surveillance and response. Surveillance officers and public health workers may be killed or missing, as in Aceh in 2004. Population displacement can distort census information, which makes the calculation of rates for comparison difficult. Healthcare during the emergency phase is often delivered by a wide range of national and international actors, which creates coordination challenges. Also, a lack of predisaster baseline surveillance information can lead to difficulties in accurately differentiating epidemic from background endemic disease transmission.
Although postdisaster surveillance systems are designed to rapidly detect cases of epidemic-prone diseases, interpreting this information can be hampered by the absence of baseline surveillance data and accurate denominator values. Detecting cases of diseases that occur endemically may be interpreted (because of absence of background data) as an early epidemic. The priority in these settings, however, is rapid implementation of control measures when cases of epidemic-prone diseases are detected. Despite these challenges, continued detection of and response to communicable diseases are essential to monitor the incidence of diseases, to document their effect, to respond with control measures when needed, and to better quantify the risk for outbreaks after disasters.
Acknowledgments
We thank Pamela Mbabazi, Jorge Castilla, Andre Griekspoor, José Hueb, Dominique Legros, David Meddings, Mike Nathan, Aafje Rietveld, and Peter Strebel for their support and assistance with the preparation of this manuscript.
Dr Watson is a medical epidemiologist with the Disease Control in Humanitarian Emergencies Program at the World Health Organization in Geneva. The program provides technical and operational support for control of communicable diseases in humanitarian emergencies.
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Tables
Table. Principles for management of dead bodies
Appendix Table. Priority measures to reduce the risk for communicable diseases after natural disasters
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《灾后疫情分析及防范》
2007年1月
John T. Watson, Michelle Gayer, Maire A. Connolly
世界卫生组织 编写
译言 翻译
更多资料正在火速翻译、校对、编排之中。请到下列网页阅读下载:
http://www.yeeyan.com/groups/show/08quake
【灾后防疫要点】
• 与自然灾害造成的直接死亡相比,灾后传染性疾病引起的死亡并不常见。
• 没有证据说明尸体会导致灾后传染病爆发。在某些特殊情况下,如霍乱或出血热,尸体才会造成传染病爆发的危险。
• 当临时迁移人群的基本生存补给不足时,传染性疾病就很可能流行。
• 持续提供安全饮用水的保障,是大灾后最重要的一项防病措施。
• 尽早发现有流行倾向的病例是保证迅速控制疫情的关键——监测/早期预警系统应及早建立。
• 应该着重关注外伤救治和伤亡人员管理,但也应该把灾后幸存者的医护需求考虑进去。
• 应尽一切努力确认尸体的身份,尽可能避免集体埋葬。家属应有机会(和条件)根据各自习俗举行适宜的葬礼和埋葬仪式。
【目录】
灾后防疫要点
摘要
尸体与疾病
首要问题:人口迁移
传染病传播的危险因素
自然灾害相关的传染性疾病
与水相关的传染病
与人群密集相关的疫病
媒介类传染病
与自然灾害相关的其他疾病
灾难中供给中断造成的疾病
讨论
鸣谢
附表一: 尸体处理原则
附表二:自然灾害后预防流行性疾病工作的优先顺序
1.水源安全,卫生条件,人员场所的安排
2.基础医疗护理条件
3.监测/早期预警系统
4.免疫
5.预防疟疾和登革热
参考资料
关于本手册
【摘要】
人们常常会误解自然灾害与传染性疾病之间的关系。人们会从尸体联想到传染病,从而担心“大灾之后必有大疫”。然而,灾后疫情爆发的风险主要是与人口迁移相关的。是否有清洁的水源和卫生设施、人群密度、人群本身的健康状况、以及是否有适当的医疗服务等,都会与当地的疫病生态相互作用,并最终影响传播性疾病爆发的风险以及感染人群的死亡率。我们在此概括了灾后引发疫病的风险因素,评估了可能发生的严重疫情,并对灾后防疫工作的轻重缓急进行疏理。
自然灾害是指大气、地质或水文等因素造成的灾变,包括地震、火山爆发、泥石流、海啸、洪水和干旱等。自然灾害可能会突然爆发,也可能缓慢发作,并对安全健康、社会和经济造成重大影响。在过去二十年中,自然灾害在全球范围已经造成数百万人死亡,并影响到十多亿人的生活,造成了无可估量的经济损失 (1)。资金不足、基础设施薄弱、缺少灾前应急方案的发展中国家在灾难中往往会受到更大创伤。
与自然灾害相关、尤其是突发灾害引起的死亡,大多来自于砸伤、压伤,或者溺水。与之相比,灾后传染性疾病引起的死亡并不太常见。
【尸体与疾病】
灾难导致的大量死亡往往会加重人们对于疾病暴发的忧虑(2),然而事实上,目前并没有证据说明大量尸体会导致灾后传染病爆发(3)。当死亡由自然灾害本身造成时,对于幸存者,并不存在引起传染病爆发的风险(4)。对于某些需要特别预防的情况,如霍乱(5)或出血热,才会存在尸体引起传染病爆发的风险。
尸体的处理原则请参阅附表一。
不管事实如何,灾后疫情爆发的可能性经常被卫生部门和媒体夸大。尽管科学家试图澄清这些缺乏根据的误区,但‘即将来临的疫情威胁’总是媒体灾区报道中反复出现的主题。
【首要问题:人口迁移】
灾后传染病的传播风险主要与人口迁移的数量和特征有关,具体包括:邻近是否有饮用水及可用的厕所,迁移人群的营养状况,人群接受过如麻疹之类的传染病免疫接种的比例,以及是否有卫生保健服务等等。(8)疫病在遭受自然灾害的人群中爆发的风险要低于遭受战争冲突的人群,后者中2/3的死亡可能是由疫病引起。(9)营养不良会增加因疫病死亡的风险,而这一情形在战争冲突中更为普遍,对于长期战乱导致的人口迁移来说尤为如此。(10)
对水灾后(11)疫病爆发的记载,比地震、火山爆发、海啸(12)后状况的记录更完备。然而总的来说,那些不会导致人口迁移的自然灾害(无论哪种类型)之后,几乎没有疫病爆发。(8)在历史上,由于自然灾害导致的大规模人口迁移并不常见,这很可能是人类历史上大规模疫病爆发并不频繁的原因之一(8),这也解释了为什么不同类型灾害后的疫病爆发风险各有差异。
【传染病传播的危险因素】
为了有效地援助受灾人群,我们需要准确地评估疫情风险。基于疫情风险评估,我们可以有侧重有先后地分配赈灾款项。
系统全面的评估疫情风险需要确认以下几点:
• 受灾地区常见的地方病和流行病;
• 灾区人群的生活状况。包括人口数量,规模,居住地点,和聚居密度;
• 洁净水的补给状况,卫生保健设备是否足够;
• 灾区人群的基本营养状况和疫苗接种率;
• 医疗保健和病例管理状况。
【自然灾害相关的传染性疾病】
以下几类传染性疾病皆与自然灾害所致流离失所的受灾人群有关。对进行灾后风险评估时,应慎重对待以下疾病。
• 与水相关的传染病
• 与人群密集相关的疫病
• 媒介传染病
• 与自然灾害相关的其他疾病
• 灾难供给中断造成的疾病
【与水相关的传染病】
安全洁净的水源,可能会因为一场自然灾害而被破坏。饮用水被污染后,腹泻类疾病可能爆发,洪水以及相关的流离失所之后也有此类的疫情报告。在2004年孟加拉国洪水后的一次爆发中,超过17000个病例出现腹泻症状;霍乱弧菌(小川血清型和稻叶血清型)、产毒大肠杆菌都曾被检出(13)
1998年,西孟加拉的一次霍乱大爆发(小川血清型,超过1.6万个病例)也被认为与之前的洪水有关(14);2000年1月到3月在莫桑比克的洪水也导致了腹泻病例的增多。
在1992-1993年印度尼西亚进行的一次大规模研究中,洪水被确定为由甲型副伤寒沙门氏菌导致的腹泻时疫的重要风险因素(16)。 2001-2003年印度尼西亚另一个有关小隐孢子虫感染的风险因素的评估研究中,与对照组相比,案例中的病人接触洪水后得病的几率是4倍以上(17)。
自然灾害后腹泻时疫爆发的风险在发展中国家比在发达国家更高(8,11)。在印度尼西亚的亚齐省,2004年12月的海啸两周后在扎朗镇的一次快速健康评测中发现,幸存者中100%曾从未得到保护的水井中饮水,而此前的两周中85%的居民报告腹泻(18)。(译者:地名译名据新华社资料库,下同)
在巴基斯坦的穆扎法拉巴德,2005年一次地震后,居住在一个事先没有规划、装备很差的营地中的1800人中爆发了严重的水性腹泻。这次爆发共有超过750个病例,其中大部分是成人。而在提供了充足的饮用水和卫生方便设施之后,疫情得到了控制(19)。
在美国,艾里森和卡特里娜飓风之后也有腹泻疾病的记录。在卡特里娜飓风中被撤离的人群中,曾检查出诺罗病毒,沙门氏菌,以及会产生毒素的霍乱胡菌等。
A型(甲型)和E型肝炎(戊型肝炎)主要通过粪-口途径传播,也与缺乏安全的水源和卫生设施有关。A型肝炎是大多数发展中国家的一种地方病,而大多数孩子因为在很小的时候曾患病而具有免疫性。因此,A型肝炎大规模爆发的几率通常就低一些。而在有E型肝炎病例的地区,该疾病通常会随暴雨和洪水的发生而爆发;这种疾病通常比较温和,而且有较强局限性,但是孕妇的死亡率可能高达百分之二十五。在2005年巴基斯坦地震后,零星的E型肝炎在那些缺乏安全水源的地区时有发生。在流离失所的难民中,发现了超过1200例急性黄疸,其中很多被确认为E型肝炎。印尼的Aceh在2004年12月海啸之后,也有集中的A型和E型肝炎病例。
细螺旋体病是一种有流行危险、通过动物传染的细菌性疾病,并可通过直接接触受污染的水进行传播。啮齿动物(鼠类)的尿液中含有大量的细螺旋体病菌,传播途径包括皮肤和粘膜与水接触、与潮湿的土壤及蔬果接触(如甘蔗)、或接触被这种尿液污染的泥巴。洪水后啮齿动物的扩散,以及人类与啮齿动物共占高地后带来的近距离接触,加剧了这种病菌的传播。2001 年中国台湾的 Nali 台风(27)、2000 年印度孟买的洪水(28)、1998 年阿根廷的洪水(29)以及 1997 年苏联克拉斯诺达尔(30),灾难过后都伴随着细螺旋体病的爆发。1996 年巴西发生了与洪水关联的细螺旋体病传染,之后的地域分析显示,在里约热内卢遭受洪水的区域,细螺旋体病的发病率增加了两倍之多(31)。
【与人群密集相关的疫病】
灾后疏散人口时常会出现人群密集,并助长传播性疫病的扩散。灾后是否出现麻疹等疫病、以及疫病传播的风险,取决于受感染人群中防疫接种率的基本状况,尤其是在15岁以下儿童中的接种率。拥挤的生存环境会助长麻疹等疫病的传染,因而需要更高的接种比例才能避免疫病爆发(32)。1991年菲律宾 Pinatubo火山爆发后,疏散的人群中爆发麻疹,18000人感染。Aceh遭受飓风后,在Aceh Utara地区出现35例小规模麻疹群发,尽管后来持续进行了防疫接种的宣传和推动,还是有个别病例或群发病例出现(26)。在巴基斯坦,2005年南亚地震后也出现了零星和群发的麻疹病例(在地震后6个月内病人超过400名)(25)。
原核生物性脑膜炎通过人与人传播,尤其在拥挤的环境中。亚齐省和巴基斯坦流离失所的人口中都有脑膜炎病例和死亡的病例(25,26)。在上述两地发生疫情时,如及时采取抗菌防疫工作应当可以阻止脑膜炎的传播。最近没有在受灾人口中大规模爆发该疫病的报告,但对由于地区冲突而迁移的人群中该疫病的爆发则有明确的记录(34)。
急性呼吸道感染(ARI)是导致灾民生病或死亡的重要原因,特别是对于5岁以下的儿童。缺乏医疗手段和抗菌药物提高了由于急性呼吸道感染(ARI)造成的死亡率。灾民面临的危险因素包括:人群拥挤、在室内使用明火煮食、和营养不良。在1998年飓风 Mitch 吹袭尼加拉瓜30天后,急性呼吸道感染(ARI)患者增加了4倍(35);而2004年印尼亚齐省海啸(26)和2005年巴基斯坦地震(25)灾害中,流离失所的灾民中患上急性呼吸道感染(ARI)和由此死亡的病例也是最多的。
【媒介类传染病】
译者注:传病媒介,医学用语,指在疾病传播过程中,使病原体(细菌、病毒、原虫、蠕虫)与感染对象(多为脊椎动物)发生联系的中介因素。传病媒介多为昆虫(双翅目昆虫、跳蚤等)但也有可能是水生软体动物。(据百度百科)
自然灾害,尤其是类似于龙卷风、飓风和洪水这样的气象灾害,会影响传病媒介孳生地以及传病媒介疾疫的传播。一方面,起初的洪水会冲刷掉现有的蚊虫孳生地,但另外一方面,暴雨或河水满溢造成的死水,也会制造出新的孳生地。
这样的状况会导致(通常是在几周的延迟之后)传病媒介群(例如蚊虫等)的增多,并导致疾疫传播。当然,这也取决于当地的媒介种类和它们所偏爱的栖息地环境。感染者或者易感人群的聚集、受到削弱的公共健康基础设施、以及现有疾病控制系统的中断,都是导致媒介传染病传播的因素(36)。
洪水过后的疟疾传播是广为人知的现象。1991年,哥斯达黎加大西洋地区的地震,导致了蚊虫孳生地的环境变化,随后就是疟疾病例的急剧上升(37)。此外,在秘鲁北部干燥的沿海地区,疟疾流行也和由“厄尔尼诺-南方振荡(译者注:指热带太平洋、印度洋之间大气质量的一种大尺度起伏振荡,是赤道附近东太平洋的一种气压异常现象。)”引起的周期性洪水有关(38)。
登革热的传播也受气候条件影响,包括降雨量和湿度,而且经常展现强烈的季候性。不过,其传播却并不与洪水直接相关。之前洪灾中爆发的案例,或许正好与疾病传播的高危期重合。另外自然灾害中基本供水系统和垃圾处理设施遭到破坏,也带来了更多的传病媒介孳生地(大多数是盛水容器),从而加重疫情。
疾疫的爆发风险也可能受到其它复杂因素的影响,比如人类行为的变化(当在外面过夜时会更多地暴露在蚊虫叮咬之下;人口从非登革热病区转移到登革热区;疾病控制活动的暂停;人口过度密集),再比如影响到蚊虫增殖的环境变动(如山崩滑坡、森林砍伐、建造河坝或水源改道等)。
【与自然灾害相关的其他疾病】
破伤风的传播途径不是从人到人,而是由厌氧性破伤风杆菌释放的有毒物质造成。在破伤风疫苗接种率低的人群中,伤口感染容易造成破伤风引起的疾病和死亡。印度洋海啸发生两周半以后,印尼亚齐(Aceh)发生了106例破伤风,其中20例死亡(26)。2005年巴基斯坦地震后同样报告了破伤风病例(25)。
1994年1月南加州地震后,爆发了罕见的球霉菌症(俗称河谷热)。这种病的感染不通过人际传播,而是由粗球霉菌造成,这种真菌存在于美国北部和南部一些半干旱区域的土壤中。地震之后发生山体滑坡,导致空气中漂浮的尘埃量增加,从而引起了这次疾病爆发(39)。
【灾难中供给中断造成的疾病】
因灾害所造成的电力中断,会造成饮用水和补给供应的中断,从而增加了由饮水途径传播疾病的机会。电力中断也会影响一些医疗设备的正常工作,包括疫苗的贮藏和低温运输。2003年纽约市大规模供电中断,造成了当地腹泻病症的大量增加。事故造成当地大约九百万居民失去电力供应,时间在数小时到两天不等。当时通过非传统的监测手段发现腹泻疾病的大规模传播。一项有关疾病控制的研究发现,停电使冰箱停止运转,腹泻是由于人们继续食用冰箱中未被保鲜的肉类和水产品而造成的(40)。
【讨论】
长久以来,“大灾之后必有大疫”的预期对公众和决策者进行判断的影响颇深。这种被误导的预期(通常是因为人们把疾病与尸体关联起来)会导致受灾人群的担忧和恐慌,并引发媒体和其它相关机构的认知混乱。
实际上,自然灾害后疫情爆发的可能性较低,当灾害没有导致大规模的人口迁移时尤其如此。而当临时迁移人群的基本生存补给(如清洁的饮用水和卫生设施、足够的临时居所场所和基本的医疗服务)不足时,传染性疾病就很可能在人群中流行。
那些容易导致疾病传播的不利条件,应当在第一时间内通过迅速恢复基础服务的方法得到改善。确保清洁的饮水和基本医疗服务是很关键的,同样关键的还有对受灾地区易发疾病的监控和预警。
全面进行传染性疾病风险评估,可以帮我们确定哪些疾病应该优先进入监控网,并为免疫接种和疾病媒介控制工作分出轻重缓急。在附录表二里总结了灾后减缓传染病传播的五个基本步骤。灾害引起的死亡绝大多数都是由外伤恶化导致的。灾难应急预案自然应该着重关注外伤救治和伤亡人员管理,但也应该把灾后幸存者的医护需求考虑进去。
对于灾后常出现的大批幸存者聚集而缺少清洁饮用水和卫生设施的情况,我们必须在救治和预防两方面都做好充分的准备。例如清洁饮用水的快速送达,治疗脱水的药品、抗生素,以及疫苗等药品的足量供应等等。受灾地区的监控对于掌握自然灾害对当地传染病致病率、致死率的相关影响是至关重要的。然而,在灾后的环境中,获得相关的监控数据通常并非易事。在灾难中,公共基础医疗设施的损坏使原本脆弱不堪的监控和反应体系更加恶化,甚至被完全破坏。就像在 2004 年 印尼亚齐(Aceh)灾难中,监控官员和公共医疗人员本身就有可能死亡或失踪。人口迁移也可能会对普查数据造成扭曲,这使得对比数据的计算更加困难。
紧急情况下的医疗卫生服务通常由多个国家和国际组织提供,这对多方协调工作是个挑战。同时,灾前基准监控数据的缺乏,给精确判断自然灾害给疾病传播带来的冲击造成困难。
虽然灾后监控系统主要针对当下(灾后)流行疾病的快速检测,但缺少基准监控数据和精确的参考值作为分母,会对检测数据的解读造成障碍。检测到的地方性流行性疾病病例可能会被解读(由于缺少背景数据)为灾后流行疾病的趋势。然而,在这种情况下,当检测到传染性疾病的病例时,应优先考虑的是快速实施控制措施。尽管面对这些挑战和困难,对传染性疾病的持续监测以及快速反应;对于监控疾病的发生、记录它们的影响、实施必要的应急控制措施、以及更好地评估灾后疾病爆发的风险起着核心的作用。
【鸣谢】
感谢pamela Mbabazi,Jorge Castilla,Andre Griekspoor,José Hueb, Dominique Legros, David Meddings, Mike Nathan, Aafje Rietveld 和Peter Strebel ,感谢他们在写作原稿过程中的协助和支持。
Watson博士是日内瓦世界卫生组织“人道主义救援行动”疾病控制项目的流行病学专家。该项目在人道主义援助行动中,传染病控制的相关问题上提供技术和操作方面的具体支持。
【附表一: 尸体处理原则】
尸体集中处理往往基于一个错误的观念:如果这些尸体没有立即埋葬或火化,将可能导致传染病的爆发。
在大量伤亡发生时,埋葬优于火化。
应尽一切努力确认尸体的身份。应尽所能,避免集体埋葬。
家属应有机会(和条件)根据各自习俗举行适宜的葬礼和埋葬仪式。
如果当前没有适当的设施,如墓地或火葬场,应提供其他临时的替代场所和设施。
对于处理尸体的工作人员,应确保
• 接触血液和尸液的通用防护措施
• 使用手套并正确处理使用过的手套
• 如有可能,应使用装尸袋
• 在处理尸体之后以及进食之前,应使用肥皂清洗双手
• 对运输工具和设备进行消毒
• 尸体处置之前无需消毒(霍乱、志贺氏细菌性痢疾以及出血热等疾病除外)
• 所有墓地的底部应高于地下水位至少 1.5 米,并保留 0.7 米的防渗透隔离层。
【附表二:自然灾害后预防流行性疾病工作的优先顺序】
[1.水源安全,卫生条件,人员场所的安排]
持续提供安全饮用水的保障,是大灾后最重要的一项防病措施。氯化物是可以广泛获得,廉价易用的药品。用它可以有效抑制水中的大多数病原菌。人员安置计划必须能够提供足够的水源,保证卫生条件,以及每个人都需要有满足国际标准最低限的空间。
[2.基础医疗护理条件]
最基本的医疗护理条件对于疾病的预防,早期诊断和常见病治疗是至关重要的。同样重要的是提供进入二级和三级医护设施的渠道。以下一些措施可以减轻传染病的影响。
• 尽早诊断和治疗腹泻和急性呼吸道感染,特别是在那些5岁以下的幼儿。
• 在疟疾高发区尽早诊断和治疗疟疾,发烧24小时内,用青蒿素为主的综合疗法来治疗恶性疟疾。
• 针对主要传染性疾病的医护和防治措置。
• 正确的伤口清洁和护理。伴随灾后的伤口处理,应予以注射破伤风疫苗(恰当选择有破伤风免疫球蛋白的疫苗或没有破伤风免疫球蛋白的疫苗)。
• 提供必要的药品,设置一个医疗应急箱,比如提供处理腹泻病的口服补液盐,治疗急性呼吸道感染的抗菌素等。
• 传播卫生知识,宣教重点在于:
好的净手习惯
安全的食物准备方式
煮沸水或氯化处理水
发烧的早期诊治
在疟疾高发区,使用杀虫剂处理过的蚊帐
与当地疾病流行情况相适应的传病媒介控制
[3.监测/早期预警系统。]
尽早发现有流行倾向的病例是保证迅速控制疫情的关键。监测/早期预警系统应及早建立,以发现疾病的爆发并监控当地重要的流行病。
• 监测系统是否应包括某种重点疾病,应基于对该传染病危险性的系统评估。
• 医疗工作者应该训练识别重点疾病,并且迅速向上级卫生部门汇报。
• 为应对疾病爆发,需要有能迅速进行化验采样,储存和运输样本的手段,以便进一步监测研究。比如,如果认为有霍乱爆发的危险,则应该准备进行霍乱相关化验的套件。
[4.免疫]
在之前没有进行广泛接种的地区,大规模麻疹免疫和补充维生素A非常重要。对于那些在小于15岁人群中接种覆盖率低于90%的区域里,应该尽快进行大面积的麻疹疫苗接种。接种的优先年龄段应该在6个月到5岁,如果资源足够的话,可上至15岁。
目前不推荐伤寒疫苗用于大面积预防伤寒病。根据当地的情况,可以把接种疫苗与其他预防手段结合,来防止伤寒在灾区的爆发。
一般来说,不推荐使用甲型肝炎疫苗用于防止该病在灾区的爆发。
霍乱疫苗的费用、处理使用该疫苗的相关后勤工作的复杂性限制了它的广泛使用。尽管霍乱疫苗在某些特定情况下是有帮助的,但并不能替代足量水和好的卫生条件。相对于其他公共卫生条件的重要性,霍乱疫苗的有效性还未在灾难波及地区得到评估。
[5.预防疟疾和登革热]
对疟疾需采取针对性的预防措施。这应该建立于对当地实际情况进行广泛评估的基础上,主要包括寄生虫类别和病菌携带源等。
灾后的大水可能推迟蚊子数量的滋长,这就给我们时间来实施预防措施,比如在室内喷洒杀虫剂,或者重新处理和安置经杀虫剂处理过的捕蚊网,特别是在那些之前已经在使用长效杀虫剂的地区。
在恶性疟疾发病的地区,应该免费提供以青蒿素为主的综合治疗。而尽快发现发烧的病例对减少死亡人数也很必要。
对于登革热,主要的预防措施应该集中于对病原携带源的控制。在社区里,应该重点动员民众消除蚊子的孳生地并进行卫生教育,具体来说:
• 保证所有储水的器皿随时用盖子封闭。
• 清除和破坏有可能存水的器皿或残骸,比如瓶子,轮胎,罐子等。
【参考资料】
略,见原文
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